KMID : 0605720140200030219
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Journal of the Korean Society of Biological Therapies in Psychiatry 2014 Volume.20 No. 3 p.219 ~ p.226
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The Relationship between the Amisulpride - Induced Weight Gain and the Dopamine D2 Receptor Genes Polymorphisms(rs1800497) in Schizophrenia Patients
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Seo Min-Jae
Woo Jung-Min Lee Jong-Hun Choi Tae-Young Kim Ji-Hyun Choi Sung-Min
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Abstract
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Objectives£ºThe aim of this study is to evaluate the association between antipsychotics-induced weight gain and the polymorphisms in the dopamine receptor D2(DRD2) genes.
Methods£ºWe measured the weight and height of 125 schizophrenia patients before and after treatment. The genotyping for rs1800497 was performed using TaqMan single nucleotide polymorphism(SNP) genotyping assay.
Results£ºThere was a significant difference in the amisulpride-induced change of body mass index(BMI) according to the frequency of rs1800497 genotype.
Conclusion£ºThis is the first positive association study between DRD2 gene and the amisulpride induced weight gain in
Korean schizophrenia patients. A larger scale research on more SNP of the DRD2 gene will make a progress in the study of amisulpride induced weight gain.
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KEYWORD
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Amisulpride, DRD2 gene, Polymorphisms, Weight gain
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